Really wonderful summary and incite and access to detail that are spot on regarding long covid. From a treatment perspective: blocking at one or more steps on the general sequential path of: stop the virus>decrease inflammation>stop histamine and stop platelet activation>stop platelet aggregation>stop microclot>stop hypoxia>stop
Mitochondrial energy changes.
An approach as a general concept (not treating advice): truvada (tdf) or paxlovid for virus. Lower dose Metformin and/or higher dose Melatonin for inflammation and viral attachment. Antihistamines H1 and H2. Aspirin and plavix for antiplatelet and nattokinase for fibrin breakdown. Probiotics for gut health (and metformin helps to get more short chain fatty acid producers). More @doc4care on twitter. Thanks again for a phenomenal article!!
Not a Dr or scientist, but a curious and voracious consumer of Covid research, so I send sincere appreciation for this relatively easy-to-understand explanation. 🙏
I am a dermatologist who has suffered LC. I agree with Dr. Haughton's comments. I would add that I have had great success using pentoxifylline 400mg TID plus aspirin 81mg and nattokinase 4000fu in my patients. I add LDN if neuro issues present but wait until their brain fog and fatigue improve on the above regimen which usually takes about 10 days. I also have used ivermectin to help with persistent spike. Six patients have paid out of pocket to have blood tested at Radiance Diagnostics for spike protein and all were positive for this in their monocytes, many a year since last infection or vaccine. Viral persistence seems to be the root cause which then triggers the microclots then..... havoc!!! I've had my own experience with P v issues and have tried just about everything out there to get better. Had to be my own advocate to get help. I also use many supplements from FLCCC.
Epstein-Barr Virus (EBV) utilizes the cellular transcription factor NFAT (Nuclear Factor of Activated T-cells) for lytic replication, particularly through its interaction with the Zta protein and the Zp promoter.
Is it possible that Pentoxifylline could have synergistic effects with other antiviral drugs, particularly those that target different aspects of EBV replication or the immune response?
Three phase 3 clinical trials are starting in 2025 to test the repurposed drugs Spironolactone, Tenofovir Alafenamide and Famciclovir for antiviral effect against Epstein-Barr virus (EBV) in MS.
This is a great question - no literature yet as far as I know, but I recently spoke with Dr. Kell and they've developed a newer, higher throughput method that uses a much larger sample volume, which will be a more accurate picture of plasma concentration. The current process only uses a few microliters of plasma, making speculations about full blood volume difficult. Excited to learn more about it when they publish.
You will be more prone to having microclots. Three patients of mine with LC had unknown thromophilia blood disorder, Factor V Leiden., that was discovered
Really wonderful summary and incite and access to detail that are spot on regarding long covid. From a treatment perspective: blocking at one or more steps on the general sequential path of: stop the virus>decrease inflammation>stop histamine and stop platelet activation>stop platelet aggregation>stop microclot>stop hypoxia>stop
Mitochondrial energy changes.
An approach as a general concept (not treating advice): truvada (tdf) or paxlovid for virus. Lower dose Metformin and/or higher dose Melatonin for inflammation and viral attachment. Antihistamines H1 and H2. Aspirin and plavix for antiplatelet and nattokinase for fibrin breakdown. Probiotics for gut health (and metformin helps to get more short chain fatty acid producers). More @doc4care on twitter. Thanks again for a phenomenal article!!
I am vax injured and in the listen study. Thank you for this information 💜❤️🩹
What is the Listen Study and how does one get involved? I have vaccine-induced LongCovid (and ME/CFS).
Go to kindred Hugo health and look up the Yale listen study on their site
Not a Dr or scientist, but a curious and voracious consumer of Covid research, so I send sincere appreciation for this relatively easy-to-understand explanation. 🙏
Thank you for all of this work you have put into this article
I am a dermatologist who has suffered LC. I agree with Dr. Haughton's comments. I would add that I have had great success using pentoxifylline 400mg TID plus aspirin 81mg and nattokinase 4000fu in my patients. I add LDN if neuro issues present but wait until their brain fog and fatigue improve on the above regimen which usually takes about 10 days. I also have used ivermectin to help with persistent spike. Six patients have paid out of pocket to have blood tested at Radiance Diagnostics for spike protein and all were positive for this in their monocytes, many a year since last infection or vaccine. Viral persistence seems to be the root cause which then triggers the microclots then..... havoc!!! I've had my own experience with P v issues and have tried just about everything out there to get better. Had to be my own advocate to get help. I also use many supplements from FLCCC.
Hope your Long Covid is getting better.
Have you seen this?
Pentoxifylline in COVID-19 and considerations for its research in long COVID
2024 Oct https://pubmed.ncbi.nlm.nih.gov/39446164
In addition to the benefits Pentoxifylline has for micro clots and excess fibrinogen, there are many references to its antiviral properties.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7923888
"Pentoxifylline also downregulates the activation of NF-κB and NFAT transcription factors (involved in the replication of several viruses)"
EBV reactivates in some Long Covid & ME/CFS, and it is also the cause of MS.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7000981/
Epstein-Barr Virus (EBV) utilizes the cellular transcription factor NFAT (Nuclear Factor of Activated T-cells) for lytic replication, particularly through its interaction with the Zta protein and the Zp promoter.
Is it possible that Pentoxifylline could have synergistic effects with other antiviral drugs, particularly those that target different aspects of EBV replication or the immune response?
Three phase 3 clinical trials are starting in 2025 to test the repurposed drugs Spironolactone, Tenofovir Alafenamide and Famciclovir for antiviral effect against Epstein-Barr virus (EBV) in MS.
https://bit.ly/Antiviral_Trials_EBV-MS
Thank YOU for creating this phenomenal resource for those of us who want to keep our fingers on the pulse of Long COVID research.
This is excellent. It's like you took all the crap in my head from all the things I've read and made it make coherent sense.
Wow, thank you for this work! I’m thrilled what comes next!
This is amazing! Honestly you should get this published somewhere
Thank you for directly acknowledging vaccine injured long haulers.
Is there any literature on the concentration of clots in the blood? What size sample would be necessary for diagnostic processes?
This is a great question - no literature yet as far as I know, but I recently spoke with Dr. Kell and they've developed a newer, higher throughput method that uses a much larger sample volume, which will be a more accurate picture of plasma concentration. The current process only uses a few microliters of plasma, making speculations about full blood volume difficult. Excited to learn more about it when they publish.
I don't want to ask but I have to ask. And if you have Prothrombin Factor II mutation?
You will be more prone to having microclots. Three patients of mine with LC had unknown thromophilia blood disorder, Factor V Leiden., that was discovered