Is reducing the activation of microglia a viable treatment strategy for long COVID and myalgic encephalomyelitis?
Thanks again Janna!
One thought I also have on LDN concerns the TRPM3-channel that seems to regulate Ca2+-influx into Natural Killer cells.
They seem dysregulated/overstimulated.
(+)-LDN seems to reverse this dysregulation in vitro in ME/CFS and LC pts.
https://pubmed.ncbi.nlm.nih.gov/31736966/
https://molmed.biomedcentral.com/articles/10.1186/s10020-022-00528-y
So mu-R antagonism seems needed in these instances.
Any thoughts on this?
Thanks again Janna!
One thought I also have on LDN concerns the TRPM3-channel that seems to regulate Ca2+-influx into Natural Killer cells.
They seem dysregulated/overstimulated.
(+)-LDN seems to reverse this dysregulation in vitro in ME/CFS and LC pts.
https://pubmed.ncbi.nlm.nih.gov/31736966/
https://molmed.biomedcentral.com/articles/10.1186/s10020-022-00528-y
So mu-R antagonism seems needed in these instances.
Any thoughts on this?