Thank you so much for this immensely clarifying paper! I was really struggling with the concept of the IDO "trap" and now I'm much closer to grasping it, as well as having better understanding of multiple biochemical interactions I've been reading about (and experiencing) for years!
Personally, I've had both severe depression and ME for decades, since my teens in the 80s, and I was trialed on pretty much every SSRI with very limited and short term benefits. Then I was given Cymbalta, ten years ago now, and have had complete remission from depression ever since. This remarkable uplift was marred by the fact that my body then proceeded to fall apart, with ME that has oscillated from Moderate to nearly Severe ever since.
I have to admit. reading your paper makes me yearn to try 5-HTP, but I will control the urge as I've given myself serotonin syndrome mixing supplements with my Cymbalta once already ;)
Again, thank you so very much for this great paper. It really helped!
Excellent paper! I was prescribed an SSRI last fall to treat my Long Covid (ME-CFS). I reacted horribly to it. The month I was on it my brain could barely function and I had an incredible nonstop headache. It was so bad I didn't even understand how bad things were until the prescription ran out and I started to come back to myself, it was like a drunk person thinking they're mostly sober and doing ok.
Hmm, I’ve been on the very journey you described: DUTCH test showed low morning cortisol. On my hellish journey through LC, I’ve had SSRI pushed on me constantly. Finally accepted in June as I have having panic attacks. Literally making myself sick (with fight/flight/fears). Just weaned off 2 weeks ago, on guidance of functional MD. Started 5-HTP last month. But now I’ll pause. I have the MECFS version of LC. IXCELA test showed low tryptophan as well. What is next? Heal the gut so I can absorb better? Eat high tryptophan foods (how does that get processed in the gut of LC folks...or does food present the same uptake issue as tryptophan supplements? Thanks for your work!
This was fascinating thank you 🙏. It mirrors my experiences.
SARS-Cov-2 binds to Ace-2 receptors on platelets, causing a prothrombin estate and reduced platelet count.
Thank you so much for this immensely clarifying paper! I was really struggling with the concept of the IDO "trap" and now I'm much closer to grasping it, as well as having better understanding of multiple biochemical interactions I've been reading about (and experiencing) for years!
Personally, I've had both severe depression and ME for decades, since my teens in the 80s, and I was trialed on pretty much every SSRI with very limited and short term benefits. Then I was given Cymbalta, ten years ago now, and have had complete remission from depression ever since. This remarkable uplift was marred by the fact that my body then proceeded to fall apart, with ME that has oscillated from Moderate to nearly Severe ever since.
I have to admit. reading your paper makes me yearn to try 5-HTP, but I will control the urge as I've given myself serotonin syndrome mixing supplements with my Cymbalta once already ;)
Again, thank you so very much for this great paper. It really helped!
Excellent paper! I was prescribed an SSRI last fall to treat my Long Covid (ME-CFS). I reacted horribly to it. The month I was on it my brain could barely function and I had an incredible nonstop headache. It was so bad I didn't even understand how bad things were until the prescription ran out and I started to come back to myself, it was like a drunk person thinking they're mostly sober and doing ok.
Hmm, I’ve been on the very journey you described: DUTCH test showed low morning cortisol. On my hellish journey through LC, I’ve had SSRI pushed on me constantly. Finally accepted in June as I have having panic attacks. Literally making myself sick (with fight/flight/fears). Just weaned off 2 weeks ago, on guidance of functional MD. Started 5-HTP last month. But now I’ll pause. I have the MECFS version of LC. IXCELA test showed low tryptophan as well. What is next? Heal the gut so I can absorb better? Eat high tryptophan foods (how does that get processed in the gut of LC folks...or does food present the same uptake issue as tryptophan supplements? Thanks for your work!